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KMID : 0613820210310070654
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Journal of Life Science
2021 Volume.31 No. 7 p.654 ~ p.661
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Biochemical Properties of a Whitening Bioactive Agent Derived from Thrichoderma viridescens SW-1
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Kang Dong-Woo
Kim Pan-Gil
Kim Sam-Woong
Bang Kyu-Ho
Kim Chul-Ho
Lee Sang-Won
Gal Sang-Wan
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Abstract
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In this study, in order to isolate excellent whitening agents from fungal cultural broth, various fungi were collected from wild areas in South Korea and then screened for tyrosinase inhibition activity, as tyrosinase is a precursor for the biosynthesis of melanin in regulating skin color. A fungus strain that inhibits tyrosinase activity has been identified and confirmed as Trichoderma viridescens (later renamed T. viridescens SW-1) via ITS sequencing. In T. viridescens SW-1, tyrosinase inhibitory activity was strongest on day three of culture. A 5% culture broth showed a tyrosinase inhibitory activity greater than 90% and exhibited high thermostability on day three. At 10% culture broth, the accumulations of intra- and extracellular melanin were inhibited above 27.1% and 7.5%, respectively. In summary, the physical and functional properties of the tyrosinase inhibitory substances of T. viridescens SW-1 included high levels of inhibition of melanin synthesis and antioxidative activity as well as thermostability. Therefore, we suggest that the whitening substance identified from the cultural broth of T. viridescens SW-1 has potential for application as a functional cosmetic ingredient.
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KEYWORD
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Cosmetics, metabolite, Trichoderma viridescens, tyrosinase inhibitor, whitening bioactive agent
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